Welcome to tepid vax summer- POLITICO

With help from Tyler Weyant

WHAT HAVE YOU DONE FOR ME LATELY Entering our third pandemic summer, it’s easy to get frustrated with the vaccines.

They aren’t as effective against variants and subvariants that keep taunting us. They aren’t preventing ongoing transmission of infection — and reinfection.

They didn’t restore our pre-pandemic normal (partly because too many people refused a vaccine, often for ideological reasons).

And we keep needing more boosters.

But the vaccines are a victim of their own success. We complain about them because we have such high expectations for them — because they’ve worked so well.

Heading into June 2022, it’s easy to forget where we were in October 2020. Back then, we were hoping for a vaccine — one vaccine — that would be at least 50 percent effective. Instead the world has numerous vaccines — and more in the pipeline.

The ones used here in the US — Pfizer, Moderna and, to a lesser extent because of the clotting risk, Johnson & Johnson — are way more than 50 percent effective at protecting us against serious disease and death. Hundreds of people are still dying from Covid-19 every day. But not thousands.

Whatever their shortcomings, the coronavirus vaccines are extraordinary. They’ve saved millions of lives, Harvard epidemiologist William Hanage reminded Nightly. The pandemic has put horrific pressures on health care systems and health care workers. But everything would have been even worse without the shots.

“Remember back in 2020, you had only one way to get immunity — to get infected. To be sick. And that was extremely high risk, for older people in particular,” Hanage said.

But that was then. Our expectations—and our pandemic fatigue—are higher now. The question for vaccines now is what’s next. The answer could come in one of several forms.

The government is now emphasizing both vaccination and treatment. White House Coronavirus Response Coordinator Ashish Jha said the other day that public health officials are “making sure that we have a new generation of vaccines that are being worked on right now, that we have availability of treatments and testing and we have the resources.”

The FDA and its advisory board are considering whether and how the vaccines should be modified to better protect against variants. The shots we get now were a response to the original or “wild” or “ancestral” version of the virus that spread throughout the world in early 2020. We’ve been through two-thirds of the Greek alphabet since then. More data about a reformulated version should come within a few weeks, an administration official told Nightly.

But even if the shots are updated to better target the virus as it exists today — or to make the protective response more enduring — it wouldn’t guarantee that a newer vaccine would protect us as effectively against yet another mutation should one arise. But broader protection should help.

The holy grail is a pan-coronavirus vaccine, one that would protect us against all variants and subtypes. The science is within reach — but so far, the money isn’t, Eric Topol, a cardiologist, med school professor and founder of the Scripps Research Translational Institute, told Nightly. Congressional Republicans have snubbed even the scaled-down pandemic spending bill President Joe Biden has requested. Nor has any international consortium, of other nations or philanthropies, stepped up to fund what is basically an Operation Warp Speed ​​Part 2.

That lack of urgency — and financing — worries Topol. “The cracks (in protection) against serious, severe disease haven’t been adequately acknowledged,” Topol said. “We’ve got chinks in the armour.”

Another path is to develop a nasal (or possibly an oral) vaccine. That would give us “mucosal immunity” — meaning it would target our noses so the virus couldn’t get in. We’d be less likely to get breakthrough infections and less likely to spread the coronavirus to others. A few are already in clinical trials.

Emily Landon, an infectious disease specialist at the University of Chicago Medicine, said the antibodies produced by a traditional injection are like “the bouncers of the immune system,” kicking viruses out of our cells before they harm us. A nasal vaccine would create “the bouncer’s bouncer” — an outer perimeter of protection.

Plus a nose spray would probably have fewer side effects, Topol said. And there are no needles, which is a bonus because needle phobia is one reason some people have shunned vaccination so far.

“Heterologous” immunity — scientists’ polysyllabic term for “mix and match” vaccines — is another potential tool. So someone who had an mRNA shot might get a booster of a more traditional kind of vaccine. It’s being studied — but it’s difficult, partly because there are so many possible combinations of vaccines and doses and intervals. (Plus, vaccine makers don’t have an incentive to do expensive studies that hand a portion of their market to a competitor).

A final pathway — and it’s not the one most of us want to hear — is that we (or at least the high risk among us) may in fact need shots twice a year for some time to come, Landon said.

We get flu shots (or we are advised to) every year — but the flu circulates for only a few months at a time. At the moment, Covid is a year-round phenomenon, rolling from one region or hot spot to another and back around, so a once a year shot isn’t enough. Plus, she said: ”Our immunity to respiratory viruses just doesn’t last very long. It never has.”

Welcome to POLITICO Nightly. Tyler here. I’ll have more to say below, but I wanted to thank all of our readers. Your time and trust in us means more than you know. Reach out with news, tips and ideas at [email protected]. Or contact tonight’s author on Twitter at @JoanneKenen.

— Michael Sussmann acquitted on charge brought by special counsel Durham: The first courtroom test for Special Counsel John Durham ended in defeat today as a federal jury found a Democratic attorney not guilty of making a false statement to the FBI about allegations of computer links between Donald Trump and Russia. The jury deliberated for about six hours before acquitting Sussmann, 57, on the single felony charge he faced: that he lied when he allegedly denied he was acting on behalf of any client in alerting the FBI to claims that a secret server linked Trump and a Moscow bank with ties to Russian President Vladimir Putin.

— Supreme Court declines to block Texas law on social media ‘censorship’: The Supreme Court blocked enforcement of a Texas law banning online platforms from restricting users’ posts based on their political views, representing a major win for social media companies. Tech industry groups had said the statute would violate the companies’ First Amendment rights and force them to carry “the vilest speech imaginable — such as white supremacist manifestos, Nazi screeds, Russian-state propaganda, Holocaust denial, and terrorist-organization recruitment.”

— Spiking temperatures could cause more blackouts this summer: Texas, the West and Midwest are bracing for potentially dangerous and costly blackouts this summer due to extreme weather and volatile gas prices — but regulators are split on how to keep the power on now and in summers to come. In the Midwest, early coal plant retirements and a lack of replacement power threaten to create a precarious gap between supply and demand as temperatures rise going into June. And aging coal and gas-fired plants across the West risk being forced to reduce their output or shut down entirely as extreme heat and drought conditions threaten their access to water and disrupt required maintenance.

— Boris Johnson could have broken ministerial code with Partygate, his standards adviser says: Boris Johnson’s standards adviser has suggested the British prime minister may have broken the ministerial code when he was fined by police for disobeying coronavirus lockdown rules. Christopher Geidt — Johnson’s independent adviser on ministers’ interests — wrote today that there was a “legitimate question” over whether Johnson had broken the code governing ministers’ behavior, in reference to the Partygate scandal concerning multiple lockdown parties in Downing Street.

EU TO AFRICA: BEWARE RUSSIA’S FOOD MESSAGE — European leaders appealed today to African countries not to fall for a Kremlin-led propaganda campaign that paints an impending global food crisis as the result of Western sanctions against Russia, Giorgio Leali and Jacopo Barigazzi write.

Africa and the Middle East risk being severely affected by Ukraine’s inability to ship its massive grain harvests out of the Black Sea, but Russian President Vladimir Putin has repeatedly accused the West of being responsible for the disruption to global supply of grains and fertilizers.

He reiterated his message last Saturday, when he told French President Emmanuel Macron and German Chancellor Olaf Scholz that ruptures in food networks should be blamed on Western countries, rather than on his invasion of Ukraine.

At a European Council summit in Brussels today, EU leaders rejected that allegation and insisted that Moscow is to blame for the blockage of grains in the port of Odessa.

STUCKS —Nightly’s Tyler Weyant emails:

“We’re in a rut.” It’s a phrase I doubt has been written in Nightly before, but it’s one we say to one another all the time, at least once every couple of months of covering the pandemic, the beat that started it all for Nightly. Occasionally, we look across the landscape of pandemic issues, and have trouble figuring out what hasn’t been said yet, what we haven’t said before.

Well, I am in my last rut at Nightly. After today, I start a new role at POLITICO, working with our exceptional Congress team.

And after hundreds of editions, doing basically every job you can have at this newsletter, I am in a rut as to what to say.

I have written nine different versions of this item in the last week and a half. A few sounded like bleak graduation speeches, one that said “I’m tired of being sad and sad about being tired” multiple times. In five of the previous editions, I used the phrase “I’m not a guy who will literally write a farewell column before going to therapy.” Cringe isn’t a strong enough word.

I tried to get out of the rut by doing things in my personal life. I went on walks. I watched Maryland win a lacrosse national championship. I rode a mechanical bull. I bought copious amounts of fudge on vacation.

But in the end, I got out of the rut the way we get out of it so often while reporting on the pandemic and other matters: I leaned into it. I wrote the rut.

What I wrote the day of the Uvalde shooting, “Mass shootings have become America’s copy and paste tragedy.” That is another rut. We are stuck in a cycle of something awful and someone needs to plainly say it.

It seems we need all the time in our current politics to clearly explain the rut. Most political issues in the country seem to be mosquitoes stuck in amber, and despite eccentric billionaires’ efforts to extract their DNA and perhaps make monsters, they are still quite stuck.

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